Fetal hemoglobin (hemoglobin F) is the main hemoglobin that carries oxygen around the body of the developing baby during the last 7 months of pregnancy. Fetal hemoglobin is best suited to the conditions in the womb and the oxygen transport needs of babies before they are born.
Background Data: Hemoglobin E. Hemoglobin E, a mutation of the beta globin gene, is probably the most common hemoglobin variant in the world. It is particularly common in India and Southeast Asia. The carrier state for Hemoglobin E (or Hb EE heterozygote) is clinically normal with minor hematologic changes. Review – How Hemoglobin D Disease, Hemoglobin SD Disease and Hemoglobin D/Beta Zero Thalassemia Disease are Inherited. If one parent has hemoglobin D trait and the other parent has sickle cell trait, there is a 25 percent (1 in 4) chance with each pregnancy of having a child with sickle cell disease (Hemoglobin SD disease).